Immunity Protocol Achievements Guide – Full List & Unlock Tips
Updated 2026-06-14

Introduction to Achievements in Immunity Protocol
Immunity Protocol features a challenging set of achievements that reward players for mastering its unique auto-shooting survival mechanics. As you pilot your immune cell sentinel through collapsing biological systems, each milestone you hit—from surviving specific waves to defeating elite pathogens—unlocks a Steam achievement. This guide covers every known achievement, its trigger condition, and strategies to earn them efficiently. Whether you are a completionist or just looking for a roadmap, you will find everything you need here.
Full Achievement List and Unlock Conditions
The game currently includes 24 achievements, ranging from simple progression rewards to difficult combat challenges. Below is the complete list:
| Achievement Name | Unlock Condition |
|---|---|
| First Contact | Survive your first pathogen wave |
| Cellular Defense | Defeat 100 enemies total |
| Symbiosis | Equip your first symbiotic upgrade |
| Wave Breaker | Reach wave 10 in any run |
| Immune Response | Upgrade a weapon to tier 3 |
| Pathogen Purge | Eliminate 500 enemies total |
| Elite Hunter | Defeat 10 elite enemies |
| Unstoppable | Reach wave 20 in any run |
| Full Arsenal | Unlock all weapon types |
| Evolution | Evolve a weapon to its final form |
| No Man Left | Complete a run without dying |
| Speed Demon | Finish wave 15 within 10 minutes |
| Collector | Unlock 5 different symbionts |
| Master of None | Reach wave 30 in any run |
| Glass Cannon | Survive 10 waves without any armor upgrades |
| Pacifist? | Win a run without killing any enemies (bosses excluded) |
| Overclocked | Activate 3 active abilities in one wave |
| Genetic Memory | Unlock all passive skill tree nodes |
| The End? | Complete the story campaign once |
| True Ending | Unlock the secret ending by collecting all lore fragments |
| Perfectionist | Earn all other achievements |
| Speedrun | Complete the campaign in under 30 minutes |
| Immortal | Survive 100 waves in a single endless run |
| Community Hero | Share a completed run screenshot on the official forum |
Some achievements like "Pacifist?" and "True Ending" require specific strategies. Check our Endings Guide for detailed walkthroughs.
Tips for Efficient Achievement Hunting
To maximize your progress, focus on achievements that overlap. For example, working toward "Wave Breaker" (wave 10) and "Immune Response" (weapon tier 3) can be done in the same run. Use the early waves to upgrade your weapons without pressure.
Refer to the Upgrades Guide for optimal weapon evolution paths that help you reach tier 3 faster.
For "Glass Cannon," avoid picking any armor upgrades during the first 10 waves. Prioritize mobility and damage symbionts instead. This pairs well with "Speed Demon" since you will clear waves quickly.
Challenging Achievements and How to Unlock Them
Some achievements require extra effort:
- True Ending: You need to collect all 8 lore fragments hidden throughout the campaign. Each fragment is in a secret room behind a destructible wall. Use the Secrets Guide for exact locations.
- Pacifist?: This is tricky. You must avoid killing regular enemies but can still defeat bosses. Use knockback symbionts to push enemies away and focus on movement speed upgrades.
- Speedrun: Finish the campaign under 30 minutes. Skip optional rooms and prioritize direct paths. The Speedrun Guide has optimal route maps.
"Pacifist?" is currently bugged in some builds. If enemies die from environmental hazards, it may not count. Restart your run if you accidentally kill anything.
Using Tools and Resources
Your loadout matters for achievement hunting. The "Collector" achievement requires unlocking 5 different symbionts—try different class builds to encounter more variety. For "Overclocked," equip three active abilities with low cooldowns and use them in quick succession during a dense wave.
- Check the Loadout Guide for recommended ability combinations
- Use the Class Guide to find which class suits each achievement best
- Track your progress using the in-game achievement menu
- Share your strategies on the community forum for "Community Hero"
Final Thoughts on Completing the List
Earning all achievements in Immunity Protocol is a rewarding journey that deepens your understanding of the game's systems. Start with the easier progression-based achievements, then tackle the challenge ones like "Immortal" (100 waves) and "True Ending." Use our other guides for detailed help on specific mechanics, and remember to enjoy the neon-drenched chaos along the way.
If you get stuck on "Immortal," try the defensive build from our Builds Guide—it focuses on health regeneration and damage reduction.
Related pages
- Crafting Guide: Blueprints & Recipes— Learn how to craft weapons, gear, and consumables in Immunity Protocol. This guide covers all crafting stations, materials, and blueprints to survive the pathogen waves.
- Currency Guide: All Resources Explained— Master the economy of Immunity Protocol with our complete currency guide. Learn how to earn and spend DNA, Plasmids, and Synaptic Credits to upgrade your immune cell sentinel effectively.
- Farming Guide: Best Ways to Farm Resources— Master resource gathering in Immunity Protocol with our comprehensive farming guide. Learn optimal routes, upgrade priorities, and strategies to maximize loot per run in this pixel auto-shooter.
- Gear Guide: Best Loadouts & Upgrades— Master the Immunity Protocol gear system with our complete guide. Learn about weapon types, symbionts, core upgrades, and optimal loadouts for every playstyle.
- Prestige Guide: How to Prestige & Rewards— Learn how the Prestige system works in Immunity Protocol. Complete guide to resetting progress, earning permanent bonuses, and optimizing your prestige runs.
- All guides
- Game page